Abstract:

Abstract:Objective To analyze the effectiveness and safety of escitalopram and venlafaxine in treatment of depression with Meta-analysis and to provide reference for their application in clinic.Methods Computer　search was performed using the Cochrane Central Register of Controlled Trial(Issue 3,2012)，Embase(1966 to 2012.09),PubMed(1948 to 2012.09),Ovid-medline(1966 to 2012.09),VIP（1989 to 2012.09），CNKI(1979 to 2012.09 and WanFang(1981-2012.09),and the randomized controlled trials (RCTs) were collected,then the retrieved studies according to predefined inclusion and exclusion criteria were screened,and the quality of included studies was evaluated and RevMan 5.2.1 software was used for Meta-analysis.Results A total of 128 articles were found and 15 of which were finally included.There was no significant difference of effectiveness between escitalopram and wenlafaxine in treatment of depression,χ2=2.56，df=14，P=1.00，Z=1.38(P＝0.17）；95%CI (0.90，1.83). The incidence of adverse reaction of escitalopram in treatment of depression was lower than that of venlafaxine,χ2=28.19，df=14，P=0.01，Z=3.16(P=0.002）；95%CI (0.50,0.85).Conclusion Escitalopram has the similar effectiveness with venlafaxine in treatment of depression,but its incidence of adverse reaction is lower than estazolam.

Key words: escitalopram , venlafaxine, depression, Meta-analysis