Fifty female SD rats were randomly divided into control group， model group， low dose of tanshinone ⅡA group， medium dose of tanshinone ⅡA group and high dose of tanshinone ⅡA group. The IUA rat models were established by curettage method. Seven days after molding， the rats in low， medium and high doses of tanshinone ⅡA groups were respectively given 5， 10 and 20 mg·kg^－1 tanshinone ⅡA， while the rats in control group and model group were given equal volume saline once a day for 14 d. HE staining was used to observe the pathomorphology of endometrium tissue of the rats in various groups. Masson staining was used to detect the fibrotsis area ratios of endometrium of the rats in various groups. Immunohistochemistry method was used to observe the expression levels of integrin αVβ3 and LIF proteins in the endometrium tissue of the rats in various groups. Real-time quantitative PCR（RT-qPCR） was used to detect the expression levels of integrin αVβ3 and LIF mRNA in the endometrium tissue of the rats in various groups.

The HE staining results showed the complete structure of uterine cavity， thick endometrium， abundant glands and orderly cell arrangement of the rats in control group； compared with control group， the cells in endometrium tissue of of the rats in model group were disorganized with fibrotic hyperplasia；compared with model group， the structures of uterine cavities of the rats in low， medium and high does of tanshinone ⅡA groups were obviously improved， the endometrium was thickened， the cell arrangement was in better order， and the fiber cells were decreased. Compared with control group， the number of endometrial glands of the rats in model group was significantly decreased （P<0.05）， while the fibrosis area ratio was significantly increased （P<0.05）， and the expression levels of integrin αVβ3 and LIF protein and mRNA were significantly decreased （P<0.05）. Compared with model group， the number of endometrial glands in low， medium and high doses of tanshinone ⅡA groups were significantly increased （P<0.05）， while the fibrosis area ratios were significantly decreased （P<0.05）， and the expression levels of integrin αVβ3 and LIF protein and mRNA were significantly increased （P<0.05）. Compared with low dose of tanshinone ⅡA group， the number of endometrial glands of the rats in medium and high doses of tanshinone ⅡA groups was significantly increased （P<0.05）， while the fibrosis area ratios were significantly decreased （P<0.05）， and the expression levels of integrin αVβ3 and LIF proteins and mRNA were significantly increased （P<0.05）；compared with medium dose of tanshinone ⅡA group， the number of endometrial glands of the rats in high dose of tanshinone ⅡA group was significantly increased （P<0.05）， while the fibrosis area ratios was significantly decreased （P<0.05）， and the expression levels of integrin αVβ3 and LIF protein and mRNA were significantly increased （P<0.05）.

Tanshinone ⅡA can improve the endometrial receptivity of the IUA rats by upregulating the expressions of integrin αVβ3 and LIF in endometrium tissue of the rats in a dose-dependent manner.