The clinical materials of a patient with HAS were collected，and the clinical features， diagnosis and treatment methods were summarized in combination with the relevant literatures.

A 54-year-old man had upper abdominal discomfort for 6 months，and was admitted to the hospital because of gastric cancer. The results of contrast enhanced CT of stomach showed infiltrating ulcerative gastric cancer and multiple liver metastases.Three courses of neoadjuvant chemotherapy were given，after that total gastrectomy was performed，and the pathological results indicated gastric adenocarcinoma.Later， the patient was transferred to our department due to multiple metastatic tumors of the liver.The patient underwent microwave radiofrequency ablation， and the pathological diagnosis was hepatoid adenocarcinoma.The pathology of stomach was confirmed by immunohistochemistry as HAS.After treatment， the survival time was only 9 months.

HAS has no specific clinical features，and can easily be misdiagnosed as gastric adenocarcinoma. The pathological diagnosis and immunohistonchemistry are the golden standard for the diagnosis of HAS. Surgical excision and postoperative adjuvant chemotherapy are the preferred treatment methods.HAS has high malignancy and rapid progression，the patients with HAS should be given early detection and treatment to prolong their survival time.