盐酸米诺环素治疗绝经妇女牙周炎患者的疗效及其对龈沟液中炎性因子和骨代谢因子的影响

doi:10.13481/j.1671-587x.20200631

Abstract

Abstract: Objective

To investigate the therapeutic effect of minocycline hydrochloride in the postmenopausal women with periodontitis and its influence in the levels of inflammatory and bone metabolism factors in the gingival crevicular fluid， and to clarify the possible mechanism of minocycline hydrochloride in the treatment of postmenopausal women with periodontitis.

Methods

According to the patients’ willing，eighty-six postmenopausal women with periodontitis were divided into minocycline hydrochloride group （observation group， n=43） and iodine glycerin group （control group， n=43）. The total effective rates of the patients in two groups were evaluated. The probing depth （PD）， plaque index （PLI）， and bleeding index （BI） of the patients in two groups were recorded and compared before treatment and 4 weeks after treatment. The levels of interleukin 6 （IL-6）， hypersensitive C-reactive protein （hs-CRP） and tumor necrosis factor-α （TNF-α） in gingival crevicular fluid of the patients in two groups before treatment and 4 weeks after treatment were measured by ELISA method and the levels of osteocalcin （OC） in gingival crevicular fluid of the patients in two groups were measured by electrochemiluminescence.

Results

There were no significant differences in PD，PLI，BI and the levels of IL-6， hs-CRP， TNF-α and OC in gingival crevicular fluid of the patients in two groups before treatment （P>0.05）. Four weeks after treatment，PD，PLI，BI and the levels of IL-6， hs-CRP， TNF-α and OC in gingival crevicular fluid of the patients in two groups were significantly lower than those before treatment （P<0.05）； compared with control group， the total effective rate of the patients in observation group was significantly increased （P<0.05），PD， PLI and BI were significantly decreased（P<0.05），the levels of IL-6， hs-CRP，and TNF-α in gingival crevicular fluid were significantly decreased （P<0.05）， and the level of OC in gingival crevicular fluid decreased was significantly decreased（P<0.05）.

Conclusion

Minocycline hydrochloride has a significant effect on the treatment of postmenopausal women with periodontitis. It can improve the periodontal parameters.

Key words: minocycline hydrochloride, postmenopause, periodontitis, interleukin-6, hypersensitive C-reactive protein, tumor necrosis factor-α, osteocalcin

CLC Number:

R781.4

Hui LI,Minghe LI,Cong ZHAO,Chang SU. Effect of minocycline hydrochloride on periodontitis in postmenopausal women and its influence in inflammatory and bone metabolism factors in gingival crevicular fluid[J].Journal of Jilin University(Medicine Edition), 2020, 46(6): 1304-1308.

Figures/Tables 4

Tab. 1

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References 24

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Group	Remarkable effect	Effective	Invalid	Total effective
Control	11（25.58）	24（55.81）	8（18.60）	35（81.40）
Observation	19（44.19）	22（51.16）	2（4.65）	41（95.35）^*

Group	PD（l/mm）		PLI（score）		BI（score）
Group	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
Control	5.44±0.67	4.16±0.92^*	2.44±0.70	1.51±0.94^*	2.88±0.85	1.28±0.91^*
Observation	5.51±0.63	3.42±1.01^*△	2.40±0.73	1.07±1.03^*△	2.98±0.74	0.84±0.87^*△

Group	IL-6		hs-CRP		TNF-α
Group	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
Control	5.48±0.67	3.49±0.63^*	17.46±2.13	12.01±1.32^*	7.58±1.15	5.47±0.66^*
Observation	5.50±0.75	3.03±0.33^*△	17.41±1.78	8.33±1.03^*△	7.56±1.11	3.81±0.55^*△

Group	OC
Group	Before treatment	After treatment
Control	648.02±65.06	450.21±54.14^*
Observation	640.53±72.42	346.51±55.22^*△

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Effect of minocycline hydrochloride on periodontitis in postmenopausal women and its influence in inflammatory and bone metabolism factors in gingival crevicular fluid

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