磁共振弥散加权成像ADC和rADC在腮腺良恶性肿瘤鉴别诊断中的应用

doi:10.13481/j.1671-587x.20200632

Abstract

Abstract: Objective

To investigate the diagnostic value of apparent diffusion coefficient （ADC） and apparent diffusion coefficient ratio （rADC）of diffusion weighted imaging（DWI） in the differentiation of benign and malignant parotid tumors.

Methods

Eighty-four patients with parotid gland tumor confirmed by pathology were selected. According to the postoperative pathological types， the patients were divided into benign tumor group and malignant tumor group.The patients received preoperative routine MRI and DWI sequence scanning.HE staining was used to detect the pathomorphology of benign and malignant parotid gland tumors and their parotid gland tumor tissue with different pathological types，and the ADC of benign and malignat parotid gland tumors and their adjacent glands of and contralateral glands of were measured， respectively.The corresponding rADC were calculated.

Results

There were 60 cases of benign parotid gland tumor and 24 cases of malignant parotid gland tumor；the benign tumor had the clear multi-boundary， and the mixed tumor and the adenomas were the most common types；the T2WI results showed the isostatic and low-signal lesions； the malignant parotid gland tumor was more common in mucoepidermoid carcinoma with irregular morphology， blurred boundaries and uneven signals， usually accompanied by invasion of peripheral structures and enlargement of cervical lymph nodes. Compared with benign parotid gland tumor，the ADC of parotid gland malignant tumor was decreased（P<0.05），and the rADC of contralateral glands and adjacent glands of parotid malignant tumor were decreased （P<0.05）；the ROC curve detection results showed that the area under the curves （AUC） of ADC， rADC of contralateral，glands， and rADC of adjacent glands were 0.859， 0.874，and 0.894， respectively.The AUC of ADC and contralateral glands and the AUC of ADC and adjacent glands were 0.874 and 0.894 calculated by combined multiple indexes.

Conclusions

The ADC and rADC of DWI can provide the reference for the diagnosis and differential diagnosis of benign and malignant parotid gland tumors， which has important clinical significance.

Key words: parotid gland tumor, magnetic resonance imaging, diffusion weighted imaging, apparent diffusion coefficient, apparent diffusion coefficient ratio

CLC Number:

R739.87

Lingxue SHI,Shuo LIU,Xuewei ZHENG,Xiaoliang CHENG,Zhaohui CHEN,Baolin MA,Hongguo ZHANG,Jun DING. Application of magnetic resonance diffusion weighted imaging ADC and rADC in differential diagnosis of benign and malignant parotid gland tumors[J].Journal of Jilin University(Medicine Edition), 2020, 46(6): 1309-1314.

Figures/Tables 7

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References 22

1	ASSILI S， FATHI KAZEROONI A， AGHAGHAZVINI L， et al. Dynamic contrast magnetic resonance imaging （DCE-MRI） and diffusion weighted MR imaging （DWI） for differentiation between benign and malignant salivary gland tumors［J］. J Biomed Phys Eng， 2015， 5（4）： 157-168.
2	李斌，潘爱珍，徐志锋. 磁共振扩散加权成像在常见腮腺肿瘤中的诊断价值［J］. 航空航天医学杂志， 2019， 30（7）：824-825， 846.
3	习志兵. MRI联合DWI检查对腮腺肿瘤患者良、恶性鉴别诊断效能的影响［J］. 现代医用影像学， 2019， 28（1）： 89-90， 94.
4	MOGEN J L， BLOCK K T， BANSAL N K， et al. Dynamic contrast-enhanced MRI to differentiate parotid neoplasms using golden-angle radial sparse parallel imaging［J］. AJNR Am J Neuroradiol， 2019， 40（6）： 1029-1036.
5	QIAN W， XU X Q， ZHU L N， et al. Preliminary study of using diffusion kurtosis imaging for characterizing parotid gland tumors［J］. Acta Radiol， 2019， 60（7）： 887-894.
6	满育平，马隆佰，林华，等. 多模态MRI对腮腺多形性腺瘤和腺淋巴瘤的诊断价值［J］. 放射学实践， 2018， 33（12）： 1241-1245.
7	王萍，张成周，王宁，等. 常规MRI联合DWI在腮腺常见肿瘤中的诊断价值［J］. 放射学实践， 2012， 27（4）： 378-381.
8	TAO X， YANG G， WANG P， et al. The value of combining conventional， diffusion-weighted and dynamic contrast-enhanced MR imaging for the diagnosis of parotid gland tumours［J］. Dentomaxillofac Radiol， 2017， 46（6）： 20160434.
9	EIDA S， SUMI M， SAKIHAMA N， et al. Apparent diffusion coefficient mapping of salivary gland tumors： prediction of the benignancy and malignancy［J］. AJNR Am J Neuroradiol， 2007， 28（1）： 116-121.
10	ARNDT C， GRAESSNER J， CRAMER M C， et al. Functional imaging of submandibular glands： diffusion-weighted echo-planar MRI before and after stimulation［J］. Rofo， 2006， 178（9）： 893-897.
11	WANG P Z， YANG J， YU Q， et al. Evaluation of solid lesions affecting masticator space with diffusion-weighted MR imaging［J］. Oral Surg Oral Med Oral Pathol Oral Radiol Endod， 2010， 109（6）： 900-907.
12	KATO H， FUJIMOTO K， MATSUO M， et al. Usefulness of diffusion-weighted MR imaging for differentiating between Warthin’s tumor and oncocytoma of the parotid gland［J］. Jpn J Radiol， 2017， 35（2）： 78-85.
13	杨功鑫，王平仲，朱文静，等.腮腺肿瘤的磁共振弥散加权成像评价[J].中国医学计算机成像杂志,2013,19(6):489-493.
14	MATSUSHIMA N， MAEDA M， TAKAMURA M， et al. Apparent diffusion coefficients of benign and malignant salivary gland tumors. Comparison to histopathological findings［J］. J Neuroradiol， 2007， 34（3）： 183-189.
15	左志超，张卫，邓文娟，等. ADC比值法对鉴别腮腺良恶性病灶的诊断价值［J］. 临床放射学杂志， 2018， 37（1）： 32-36.
16	潘桂海，周飞，陈武标，等. 3.0 T MRI动态增强对腮腺肿瘤良恶性的鉴别及其ADC值与病理分级的相关性研究［J］. 临床放射学杂志， 2019， 38（6）： 1002-1006.
17	王毅，赖清泉，黄美玲，等.磁共振体素内不相干运动在肺良恶性肿瘤的诊断效能及肿瘤化疗疗效评估的应用［J］.中国医学物理学，2019，36（6）： 682-688.
18	ZHU L， WANG J B， SHI H M， et al. Multimodality fMRI with perfusion， diffusion-weighted MRI and ¹ H-MRS in the diagnosis of lympho-associated benign and malignant lesions of the parotid gland［J］. J Magn Reson Imaging， 2019， 49（2）： 423-432.
19	ZHANG Z X， SONG C R， ZHANG Y， et al. Apparent diffusion coefficient （ADC） histogram analysis： differentiation of benign from malignant parotid gland tumors using readout-segmented diffusion-weighted imaging［J］. Dentomaxillofac Radiol， 2019， 48（7）： 20190100.
20	RIES T， ARNDT C， REGIER M， et al. Value of apparent diffusion coefficient calculation before and after gustatory stimulation in the diagnosis of acute or chronic parotitis［J］. Eur Radiol， 2008， 18（10）： 2251-2257.
22	刘晟.磁共振灌注成像在高级别脑胶质瘤与单发脑转移瘤鉴别诊断中的价值[J].中国医学物理学杂志,2019,36(7):808-810.

Group	n	ADC （×10^－3mm²·s^－1）	rADC of contralateral gland	rADC of adjacent gland
Benign parotid gland tumor	60	1.21±0.25	0.11±0.27	0.20±0.30
Malignant parotid gland tumor	24	0.90±0.12	－0.24±0.14	－0.19±0.14
t		7.053	7.097	7.239
P		<0.01	<0.01	<0.01

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Application of magnetic resonance diffusion weighted imaging ADC and rADC in differential diagnosis of benign and malignant parotid gland tumors

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