A total of 50 female BALB / c mice were randomly divided into control group， OVA model group， low，middle and high doses of PD groups；there were 10 mice in each group.The experimental asthmatic mouse models were established by OVA induction and stimulation. The mice were sensitized by intraperitoneal injection the mixture of OVA and Al （OH）₃ on the 1st， 7th and 14th days of experiment. From the 21st day， the mice in different doses of PD groups were injected with 15，30，and 45 mg·kg^－1 PD， while the mice in control group and OVA group were given normal saline. HE and PAS staining were used to observe the pathomophology of lung tissue of the mice in various groups； Diff-Quick method was used to detect the total number of cells and the number of eosinophils， neutrophils and lymphocytes in bronchoalveolar lavage fluid（BALF）； the levels of IL-4， IL-5， and IL-13 in BALF of the mice in various groups were detected by ELISA method； immunohistochemistry was used to observe the expressions of SIRT1 and NF-κB p65 in lung tissue of the mice in various groups； Western blotting method was used to detect the expression levels of SIRT1 protein and acetylized NF-κB p65 protein in lung tissue of the mice in various groups.

Compared with control group，the airway wall of the mice in OVA group was thickened， a large number of inflammatory cells infiltrated around the airway and the goblet cells were proliferated significantly.Compared with OVA group，the findings mentioned above in different doses of PD groups were improved. Compared with control group， the total number of cells，the number of eosinophils， neutrophils，and lymphocytes and the levels of IL-4， IL-5， and IL-13 in BALF of the mice in OVA group were increased （P<0.05）. Compared with OVA group， the total number of cells，the number of eosinophils and neutrophils， and the levels of IL-4， IL-5， and IL-13 in BALF of the mice in middle and high doses of PD groups were decreased （P<0.05）. Compared with control group， the expression levels of SIRT1， NF-κ B p65 and acetylized NF-κB p65 proteins in lung tissue of the mice in OVA group were significantly increased （P<0.05）. Compared with OVA group， the expression levels of SIRT1 protein in lung tissue of the mice in middle and high doses of PD groups were increased （P<0.05）， while the expression levels of NF-κB p65 and acetylized NF-κB p65 proteins in ling tissue of the mice in middle and high doses of PD groups were decreased （P<0.05）.

PD can alleviate the airway inflammation in the asthmatic mice， and its mechanism may be related to the SIRT1/NF-κB pathway.