Fifty clean BALB/c female mice were randomly divided into control group， ovalbumin （OVA） group， low dose of SAL group， high dose of SAL group and dexamethasone group， and there were 10 mice in each group. The mouse asthma model was established by intraperitoneal injection of 200 μL mixed solution （containing normal saline， 10 mg OVA， and 1 mg aluminum hydroxide） on the 1st， 7th and 14th days. On the 21st day， the sensitized mice were placed in the experimental glass box. In the box，the mice were stimulated with 0.1 g OVA+10 mL physiological saline pulverization for 30 min， once a day， lasted for 7 d.^{The mice in low and high doses of SAL groups were intraperitoneally injected with 30－60 mg·kg－1 SAL treatment solution 1 h before each challenge， and the mice in dexamethasone group were intraperitoneally injected with 2 mg·kg－1 dexamethasone treatment solution， while the mice in control group were replaced with the same dose of saline. The enhanced pause（Penh） values of the mice in various groups were detected and the airway reactivities of the mice were evaluated； the morphology of lung tissue of the mice in various groups was observed by HE staining； the numbers of neutrophils， eosinophils and lymphocytes in alveolar lavage fluid （BALF） of the mice in various groups were calculated by direct counting method； ELISA method was used to detect the levels of interleukin 1β （IL-1β）， interleukin 4 （IL-4）， interleukin 13 （IL-13），interleukin 17A （IL-17A）， interleukin 18 （IL-18） ，and interleukin 33 （IL-33） in BALF of the mice in various groups； the expression level of NOD-like receptor family protein 3 （NLPR3），apoptosis-associated speck-like protein containing a CARD （ASC），Caspase-1， interleukin-1β precursor （pro-IL-1β） and IL-1β proteins in lung tissue of the mice in various groups were determined by Western blotting method.}

Compared with control group， the Penh value of the mice in OVA group was increased （P<0.05）； compared with OVA group， the Penh value of the mice in high dose of SAL group was increased （P<0.05）. Compared with control group， the airway smooth muscle of the mice in OVA group was thickened and a large amount of inflammatory cell infiltration was seen； compared with OVA group，the number of inflammatory cells around the airway of the mice in high dose of SAL group was decreased （P<0.05）. Compared with control group， the numbers of neutrophils， eosinophils and lymphocytes in BALF of the mice in OVA group were increased （P<0.05）.The levels of IL-1β， IL-4， IL-13， IL-17A， IL- 18， and IL-33 in BALF of the mice in OVA group were significantly increased （P<0.05）；compared with OVA group， the numbers of neutrophils， eosinophils and lymphocytes in BALF of the mice in high dose of SAL group were decreased （P<0.05）， the levels IL -1β， IL-4， IL-13， IL-17A， IL-18 ，and IL-33 in BALF of the mice in OVA group were decreased （P<0.05）. Compared with control group， the expression levels of NLPR3， ASC， Caspase-1， pro-IL-1β ，and IL-1β proteins in lung tissue of the mice in OVA group were significantly increased （P<0.05）； compared with OVA group， the expression levels of NLPR3， ASC， Caspase-1，pro-IL-1β ，and IL-1β proteins in lung tissue of the mice in high dose of SAL group were decreased （P<0.05）.

SAL can reduce the airway inflammation in the mice with acute asthma， and its mechanism may be related to down-regulation the expression of NLRP3 inflammasome.