Abstract:

Objective To explore the feasibility of the treatment strategy of no treatment and only regular follow-up for the patient with asymptomatic postmenopausal pulmonary benign metastasizing leiomyomat（PBML）， and to provide a reference for the diagnosis， treatment， and prognosis of the disease. Methods The clinical characteristics， examination results， and follow-up results of a patient with PBML were analyzed retrospectively， and the pathogenesis and treatment measures were discussed in combination with the literature review. Results The female patient， 52 years old，was admitted to the hospital due to the physical examination of multiple nodules in both lungs， and previously underwent total hysterectomy for multiple uterine leiomyomas. There were no obvious pulmonary signs，and imaging examination showed multiple round nodular hyperdense shadows in both lungs. Percutaneous biopsy of pulmonary nodules was performed under the guidance of computed tomography （CT） in the left lung. The pathological diagnosis was PBML， and estrogen receptor（ER） and progesterone receptor（PR） were positive. The patient’s sex hormone level was in menopause，so no treatment was given， and regular imaging examinations and follow-up were carried out. The CT follow-up at 5， 11， 20， and 34 months after percutaneous lung puncture showed that no obvious enlargement of bilateral pulmonary nodules was found， and no cough， wheezing and other discomfort symptoms were found at 41 months. Conclusion The asymptomatic female PBML patients with hormone levels in menopause may not be treated and only need the regular imaging follow-up.

Key words: Benign metastasizing leiomyoma, Uterine neoplasms, Neoplasm metastasis, Lung neoplasms