let-7和HMGA2在肺癌发生发展中作用的Meta分析

doi:10.13481/j.1671-587x.20160614

Abstract

Abstract:

Objective: To evaluate the role of low expression of let-7 in the prognosis of lung cancer and the clinical significance of relationship between the HMGA2 expression and lung cancer by Meta-analysis method.Methods: The studies about the correlation between the low expression of let-7 and the prognosis of lung cancer and the correlation between the HMGA2 expression and the occurrence and development of lung cancer were collected by searching PubMed,Web of Science,Medline,Cochrane Library,Google, Scholar,CNKI,CBM,and Wanfang,and VIP databases.The StataSE 12.0 software was used for this Meta-analysis.Results: A total of 10 studies about the relationship between the low expression of let-7 and the prognosis of lung cancer (the patients with non-small cell lung cancer) were enrolled in this Meta-analysis.The low expression of let-7 indicated a poor overall survival rate,and the combined value of hazard ratio(HR) was 1.55 (95%CI:1.16-2.09,P<0.05).A total of 9 case-control studies about the relatlonship between the expression of HMGA2 and the occurrence and development of non-small cell lung cancer were selected for this Meta-analysis. The positive expression rate of HMGA2 in lung cancer tissue was significantly higher than that in paracancer normal tissue(OR=5.92,95% CI:3.96-8.85,P=0.000).The expression of HMAG2 in lung cancer tissue was pasitively related with the TNM stage and the lymph node metastasis of the patients(OR=0.26,95%CI:0.16-0.41,P<0.05;OR=0.29,95%CI:0.12-0.71,P<0.05).Conclusion: The low expression of let-7 is closely related to the poor prognosis of lung cancer patients.The highly positive expression rate of HMGA2 in lung cancer tissue is positively correlated with the occurrence and invasiveness of lung cancer.

Key words: lung neoplasms, prognosis, let-7, Meta-analysis, high mobility group A2

CLC Number:

R734.2

LI Xingxing, TAN Jingjin, JIANG Shan, WAHG Ke. Role of let-7 and HMGA2 in occurrence and development of lung cancer: Meta-analysis[J].Journal of Jilin University Medicine Edition, 2016, 42(06): 1116-1125.

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Role of let-7 and HMGA2 in occurrence and development of lung cancer: Meta-analysis

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