Abstract:

Objective： To analyze the clinical characteristics and diagnosis and treatment of the patient with primary ovarian dedifferentiated liposarcoma （DDLPS）， and to improve the clinicians’ understandings of the disease and the levels of diagnosis and treatment. Methods The clinical data of one patient with primary ovarian DDLPS was colected，and the clinicopathological manifestations， diagnosis， differential diagnosis， treatment， and prognosis were retrospectively analyzed， and the related literatures were reviewed. Results A 63-year-old female patient was admitted to hospital because of a huge mass in the lower abdomen for half a month. The gynecological ultrasound results showed there was a solid hypoechoic mass，with the size of 17.0 cm × 9.3 cm， with an irregular shape and a clear boundary in the middle pelvic cavity after hysterectomy， and there were blood flow signals in the periphery； the bilateral ovaries were not found. The whole abdominal CT results showed there was a huge mixed-density mass in the pelvic cavity， with the lobed lobes and poorly defined boundaries； the size was about 132 mm×86 mm， and the CT value was about 33 HU. The enhancement scaning results showed obvious uneven enhancement of the lesion， obvious enhancement of the edge， and no obvious enhancement of the low-density shadow in the pelvic cavity； the multiple lymph node shadows with the diameter smaller than 6 mm were seen in the pelvic cavity， and the CT enhancement scaning results showed that the lymph nodes were slightly enhancement.The tumor markers had no significant abnormalities. The patient was diagnosis as pelvic mass and the probability of ovarian malignancy was high. After completing all the relevant examinations， the transabdominal bilateral salpingectomy and oophorectomy were performed after general anesthesia. The results of the pathological diagnosis after operation were ovarian DDLPS. No recurrence of the patient was found 10 months after operation. Conclusion The primary ovarian DDLPS is rare， and the clinical manifestations are not specific； imagological methods are helpful for the diagnosis； radical surgery is the main treatment method； targeted therapy can bring good efficacy for the patients； the disease has high malignancy， poor prognosis， and it is easy to relapse； so long-term follow-up should be performed.

Key words: Ovarian neoplasm, Primary, Dedifferentiated liposarcoma, Prognosis