生物可降解明胶微球的制备及体外降解

生物可降解明胶微球的制备及体外降解

姜丹¹, 唐召军², 姜云垒³, 刘成柏¹, 王飞¹, 林相友¹, 陈霞¹

1. 吉林大学生命科学学院, 长春 130021； 2. 河南大学特种功能材料重点实验室, 河南开封 475001； 3. 吉林农业大学动物科技学院, 长春 130018

收稿日期:2007-03-09 修回日期:1900-01-01 出版日期:2008-01-26 发布日期:2008-01-26
通讯作者: 陈霞

Preparation and Invitro Degradation of BiodegradableGelatin Microspheres

JIANG Dan¹, TANG Zhaojun², JIANG Yunlei³, LIU Chengbai¹, WANG Fei¹, LIN Xiangyou¹, CHEN Xia¹

1. College of Life Science, Jilin University, Changchun 130021, China;2. Lab of Special Function Materials, Henan University, Kaifeng 475001, Henan Province, China;3. College of Animal Technology, Jilin Agricultural University, Changchun 130018, China

Received:2007-03-09 Revised:1900-01-01 Online:2008-01-26 Published:2008-01-26
Contact: CHEN Xia

摘要/Abstract

摘要： 以生物可降解明胶为载体, 采用乳化交联法制备明胶微球, 考察了固化剂加入时间对微球质量的影响, 并通过正交实验研究了明胶溶液的浓度、搅拌速度、水油相比例对微球粒径的影响. 结果表明, 所制备的明胶微球, 具有粒径均一、成球率高的特点, 微球表面平滑, 平均粒径为13.72 μm.

关键词: 明胶, 微球, 乳化交联法, 固化剂, 正交设计

Abstract: Gelatin microspheres were prepared by means of emulsion chemicalcrossline technique. In order to gain the best homogeneous size and p arameters, it was demonstrated that solidifying reagent adding time had effects on gelatin microspheres. The preparation conditions of the microspheres such as gelatin concentration, agitate rate, ratio of water to oil phase were studied and discussed. The surface morphology and the size of the microspheres were observed by SEM. The result shows that the microspheres prepared have relatively uniform diameter, the average diameter in this study is 13.72 μm, and the surface of the microspheres is smooth.

Key words: gelatin, microsphere, emulsion chemicalcrossline technique, solidifying reagent, orthogonaldesigning method

中图分类号:

R944.9

姜丹, 唐召军, 姜云垒, 刘成柏, 王飞, 林相友, 陈霞. 生物可降解明胶微球的制备及体外降解[J]. J4, 2008, 46(01): 143-147.

JIANG Dan, TANG Zhaojun, JIANG Yunlei, LIU Chengbai, WANG Fei, LIN Xiangyou, CHEN Xia. Preparation and Invitro Degradation of BiodegradableGelatin Microspheres[J]. J4, 2008, 46(01): 143-147.

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