肿瘤标志物联合检测在原发性肝细胞癌早期诊断中的应用

肿瘤标志物联合检测在原发性肝细胞癌早期诊断中的应用

罗速^{1，2^{, 张逢春¹, 刘成柏³, 项小丰¹}}

1. 北华大学医学院检验系，吉林 132013； 2. 吉林大学酶学工程教育部重点实验室，长春 130023； 3. 吉林大学生命科学学院分子生物学系，长春 130023

收稿日期:2004-03-19 修回日期:1900-01-01 出版日期:2004-10-26 发布日期:2004-10-26
通讯作者: 罗速

A combined examination of tumor marker for early diagnosis of primary hepatocellular carcinoma

LUO Su^1，2, ZHANG Feng-chun¹, LIU Cheng-bai³, XIANG Xiao-feng¹

1. Department of Examination， Medical College, Beihua University, Jilin 132013, China; 2. Key Laboratory of Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun 130023, China。3. Department of Molecular Biology， College of Life Science， Jilin University , Changchun 130023, 　China

Received:2004-03-19 Revised:1900-01-01 Online:2004-10-26 Published:2004-10-26
Contact: LUO Su

摘要/Abstract

摘要： 用生物发光免疫分析法、比色法联合检测确诊的原发性肝细胞癌（53例）、乙型病毒性肝炎（80例）、慢性乙肝合并肝硬化（34例）患者同份血清的肿瘤标志物甲种胎儿蛋白( AFP)和肿瘤特异性生长因子(TSGF)．　结果显示，原发性肝细胞癌组血清TSGF和AFP与其他组比较均有显著差异（P<0.01）；原发性肝癌组中TSGF与AFP联合阳性检出率为96.2 %．关键词: 生物发光免疫分析技术；甲种胎儿蛋白；肿瘤特异性生长因子；原发性肝细胞癌

关键词: 生物发光免疫分析技术, 甲种胎儿蛋白, 肿瘤特异性生长因子, 原发性肝细胞癌

Abstract: The bioluminescence immunoassay technique was combined with the colo rimetric method to detect the tumor marker α-fetoprotein(AFP) and tumor specific growth factor(TSGF) of the patients sera of primary hepatocellular car cinom a(53 patients), hepatitis (80 patients) and hepatocirrhosis (34 patients). The re sults show that AFP and TSGF in primary hepatocellular carcinoma sera have signi ficance difference from those in other groups(P<0.01); the positive rate of AFP and TSGF by combined examination was 96.2%. The combined examination of A FP and TSGF can raise the diagnostic rate of primary hepatocellular carcinoma.

Key words: bioluminescence immunoassay, α-fetoprotein, tumor specific growth factor, primary hepatocellular carcinoma

中图分类号:

Q953

罗速, 张逢春, 刘成柏, 项小丰. 肿瘤标志物联合检测在原发性肝细胞癌早期诊断中的应用[J]. J4, 2004, 42(04): 625-627.

LUO Su, ZHANG Feng-chun, LIU Cheng-bai, XIANG Xiao-feng. A combined examination of tumor marker for early diagnosis of primary hepatocellular carcinoma[J]. J4, 2004, 42(04): 625-627.