用电喷雾四极杆飞行时间质谱研究头孢类药物的质谱裂解规律

用电喷雾四极杆飞行时间质谱研究头孢类药物的质谱裂解规律

王玲¹，王英武²，陈刚¹，周秀清¹ ，单洪岩¹

１.　吉林大学测试科学实验中心，长春 130023；２.　吉林大学生命科学学院，长春 130023

收稿日期:2002-06-23 修回日期:1900-01-01 出版日期:2003-01-26 发布日期:2003-01-26
通讯作者: 王玲

Fragmentation Regularities of Cephalosporin Drugs by Means of Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry

WANG Ling¹， WANG Ying-wu²， CHEN Gang¹， Z HOU Xiu-qing¹， SHAN Hong-yan¹

1. Analysis Test & Experiment Center, Jilin University， Changchun 130023， China； 2. College of Life Science, Jilin University， Changchun 130023， China

Received:2002-06-23 Revised:1900-01-01 Online:2003-01-26 Published:2003-01-26
Contact: WANG Ling

摘要/Abstract

摘要： 利用电喷雾四极杆飞行时间质谱研究了3种常用头孢类药物的质谱裂解行为. 二级质谱数据结果显示：在正离子模式下， β-内酰胺结构不太稳定，在C（6）_C（7）和C（8）_N（1）键处易于断裂，进而形成稳定的共轭结构，此类药物易失去中性碎片NH₃.

关键词: 头孢, 电喷雾四极杆飞行时间质谱, 碰撞诱导解离

Abstract: The structural fragmentation of three cephalosporins in electrospray ionization conditions was studied by electrospray ionization quadrupole time-of-flight mass spectrometry in positive mode. Some common fragmentation pathways were found to be closely related to the substituent of the 7-aminocephalosporin nucle us. The product ion experiments turned out to be an essential technique to draw the fragmentation patterns of compounds. The results suggest that electrospray ionization quadrupole time-of-flight mass spectrometry is an ideal instrument to investigate the fragmentation pathways of drugs.

Key words: cephalosporins, electrospray ionization quadrupole time-of-flight ma ss spectrometry, collision-induced dissociation

中图分类号:

O656

王玲，王英武，陈刚，周秀清，单洪岩. 用电喷雾四极杆飞行时间质谱研究头孢类药物的质谱裂解规律[J]. J4, 2003, 41(01): 117-119.

WANG Ling， WANG Ying-wu， CHEN Gang， Z HOU Xiu-qing， SHAN Hong-yan. Fragmentation Regularities of Cephalosporin Drugs by Means of Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry[J]. J4, 2003, 41(01): 117-119.