仿水溶剂促进酶促拆分环氧丙醇的研究

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Enzymatic resolution of glycidol improved by water-mimicking solvent

WANG Zhi¹, GOU Xiao-jun², YU Da-hai¹, ZHENG Liang-yu¹, WENG Liang¹, ZHANG Gui-rong¹, CAO Shu-gui¹

1. Key Laboratory for Molecular Enzymology and Engineering of Educational Ministry, Jilin University, Changchun 130023, China; 2. Key Laboratory of Molecular Evolution and Engineering, Department of Biology Engineering, Chengdu University, Chengdu 610106, China

Received:2003-06-26 Revised:1900-01-01 Online:2004-01-26 Published:2004-01-26
Contact: CAO Shu-gui

Abstract

Abstract: The asymmetric esterification of glycidol catalyzed by lipase was carried out in a nonaqueous medium. The effect of the replacement of water necessary for the funct ion of lipase with water-mimicking solvent on the resolution was investigated. It's found that the water produced from enzymatic esterification could be removed s uccessfully by addition of acetonitrile(0.4%, volume fraction) and 0.04　g anhydrous Na₂SO₄ into the reaction system. Under the optimal conditions, R- glycidyl butyrate with about ee 90% was prepared.

Key words: glycidol, lipase, esterification, water-mimicking solvent

CLC Number:

WANG Zhi, GOU Xiao-jun, YU Da-hai, ZHENG Liang-yu, WENG Liang, ZHANG Gui-rong, CAO Shu-gui. Enzymatic resolution of glycidol improved by water-mimicking solvent[J].J4, 2004, 42(01): 126-129.

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Enzymatic resolution of glycidol improved by water-mimicking solvent

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