Abstract: To investigate the pharmacokinetic characteristics of Armillarisin A and its absolute bioavailability in rats, 1.44 mg and 0.9 mg of Armillarisin A were given via ig and iv to SD rats, respectively; the plasma concentration of Armillarisin A in rats was determined by LCMS/MS. After ig administration of Armillarisin A, the main pharmacokinetic parameters c_max, t_1/2, AUC_0~t were (58.33±23.41) μg/L, (155±043) h, (4187±754) h·(μg/L), respectively; After iv administration of Armillarisin A, the major pharmacokinetic parameters c_max, t_1/2, AUC_0~t were (825.25±92.13) μg/L, (0.75±0.35) h, (140.64±19.73) h·(μg/L), respectively. The absolute bioavailability was 18.61% after correction of dosage.

Key words: Armillarisin A, pharmacokinetics, absolute bioavailability