松杉灵芝多糖的抗突变作用

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Anti-mutagenic Effects of Polysaccharides from Ganoderma Tsugae

ZHENG Ke-yan¹, ZHANG Jie⁴, LIN Xiang-you²,LI Fang-liang², YOU Yu-run³, FEI Xiao-fang²

1. Teaching and Research Center of Chemistry, Jilin University, Changchun 130023, China;2. Department of Biology Pharmaceutics, College of Life Sciences, Jilin University, Changchun 130023, China; 3. National New Drug Safety Estimate Center, Shenyang 110021, China; 4. College of Pharmaceutics, Changchun College of Traditional Chinese Medicine, Changchun 130117, China

Received:2004-07-13 Revised:1900-01-01 Online:2005-03-26 Published:2005-03-26
Contact: FEI Xiao-fang

Abstract

Abstract: The anti-mutagenic effects of polysaccharides from Ganoderma tsugae were studied by mice bone marrow cell micronuclei test, mice testicular chromosome aberration test and Ames test. The micronuclei frequency induced by cyclophosphamide in mouse bone marrow cells was inhibited significantly, but mouse testicular chromosome aberration frequency induced by mitomycinc was not inhibited markedly by polysaccharides from Ganoderma tsugae. The Ames test showed that polysaccharides from Ganoderma tsugae have effectively anti-mutageni activties.

Key words: polysaccharides from Ganoderma tsugae, anti-mutagenic, aberration

CLC Number:

R392.11

ZHENG Ke-yan, ZHANG Jie, LIN Xiang-you,LI Fang-liang, YOU Yu-run, FEI Xiao-fang. Anti-mutagenic Effects of Polysaccharides from Ganoderma Tsugae[J].J4, 2005, 43(02): 235-237.

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Anti-mutagenic Effects of Polysaccharides from Ganoderma Tsugae

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