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The Newly Development of theEnzymecatalyzed Resolution Methods and Application

ZHANG Guoyan¹,², CAO Shugui¹

1. Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, Jilin University,Changchun 130021, China; 2. College of Chemistry, Jilin University, Changchun 130021, China

Received:2007-09-14 Revised:1900-01-01 Online:2008-09-26 Published:2008-09-26
Contact: ZHANG Guoyan

Abstract

Abstract: The present paper described the recent research and application of chiral resolution by enzyme {catalysis}. The methods of kinetic resolution, dynamic kinetic resolution and enantioconvergence resolution were compared with each other. The steoroselective hydrolysis, transesterification and acylation of esters and amines catalyzed by enzymes, in particular, hydrolases in non-aqueous solution were also introduced {according} to the progress of research and the problems of technology.

Key words: chiral resolution, kinetic resolution, dynamic kinetic resolution, enantioconvergence

CLC Number:

Q814

ZHANG Guoyan,, CAO Shugui. The Newly Development of theEnzymecatalyzed Resolution Methods and Application[J].J4, 2008, 46(05): 997-1000.

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The Newly Development of theEnzymecatalyzed Resolution Methods and Application

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