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Study on the Metabolites of Aconitine in Rabbit Blood

ZHANG Hong-gui1, SHI Xiang-guo2, SUN Ying3, ZHONG Da-fang2, ZHANG Han-qi1   

  1. (1. College of Chemistry, Jilin University, Changchun 130012, China; 2. Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang 110016, China; 3. Changchun Medical College, Changchun 130031, China)
  • Received:2005-03-07 Revised:1900-01-01 Online:2006-03-26 Published:2006-03-26
  • Contact: ZHANG Han-qi

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Abstract: Aconitine and its three metabolites were separated and identified in the blood of dead rabbits after aconitine poisoning by means of liquid chromatography-electrospray ion trapmass spectrometry (LC-ESI-MS). 16-O-demethylbenzoylaconine in the blood of the animal that was administered aconitine was found for the first time. The metabolic pathway of aconitine in the blood was studied.

Key words: aconitine, metabolite, liquid chromatography-electrospray ion trap-mass spectrometry

CLC Number: 

  • R927
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