川丁特罗对大鼠细胞色素P450酶的影响

J4 ›› 2010, Vol. 48 ›› Issue (06): 1061-1064.

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Effect of Trantinterol on Cytochrome P450 Enzymes

SUN Yantong^1,2, GAO Feng¹, ZHANG Mengliang¹, CUI Xiangyong¹,WANG Zhonghua¹, GU Jingkai¹

1. Research Center for Drug Metabolism, College of Life Science, Jilin University, Changchun 130012, China;
2. College of Pharmaceutical Sciences, Jilin University, Changchun 130021, China

Received:2010-03-15 Online:2010-11-26 Published:2010-11-26
Contact: GU Jingkai E-mail:gujk@mail.jlu.edu.cn

Abstract

Abstract:

To study the effect of trantinterol on cytochrome P450 (CYP450) in rat liver microsomes, rats were given single daily oral doses of trantinterol or saline for one week. Liver microsomes were prepared and the effects of treatment on the total CYP450 content and the activities of CYP1A2, CYP2D6, and CYP3A4 were determined. The latter employed phenacetin, debrisoquine and midazolam respectively as probe substrates. The results indicate that the level of total CYP450 and the activities of CYP1A2, CYP2D6, and CYP3A4 in rat liver microsomes were unchanged after treatment by trantinterol (P>0.05). Chronic oral administration of trantinterol did not lead to the induction of the representative enzymes of the main drug metabolizing CYP450 subfamilies.

Key words: trantinterol, cytochrome P450, rat

CLC Number:

R969.1

SUN Yan-Tong, GAO Feng, ZHANG Meng-Liang, CUI Xiang-Yong, WANG Zhong-Hua, GU Jing-Kai. Effect of Trantinterol on Cytochrome P450 Enzymes[J].J4, 2010, 48(06): 1061-1064.

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Effect of Trantinterol on Cytochrome P450 Enzymes

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