Abstract: The cell adhesive effects of four peptides containing RGD，RGDS，RGD-(NH₂)₂ and RGDS-NH₂ on Human Intestines Cancer (HCT-8)， Human Osteogenic Sarconia (OS732) were investigated. First of all， these cell adhesion peptides were immobilized on PLGA blend membrane respectively and their effects on cell adhesion were investigated. The four peptides except RGD-(NH₂)₂ on the membrane can promote the cell adhesion to the membrane. On the other hand，MTT assay was used to examine the adhesion of HCT-8 cells and OS732 cells on the Fibronectin (FN) after treatment with cellular adhesion peptide， we found that cellular adhesion peptides RGDS，RGDS-NH ₂，RGD significantly inhibited the adhesion of HCT-8 cells and OS732 cells on the FN in dosedependent manner. RGD-(NH₂)₂ does not show an obvious ability to inhibit cell adhesion.The maximum percentages of inhibition were 53.3%，56.3%，37.5% on HCT8 and 50.9%，49.8%，34% on OS732 by RGDS，RGDS-NH₂，RGD，respectively. 

Key words: cellular adhesion peptide, RGD, PLGA, HCT-8, OS732, fibronectin