2-乙酰氨基-2-［2-(4-正辛基苯基)乙基］丙二酸二乙酯的环合反应

Cyclization of Diethyl 2-Acetamido2-［2-(4-octylphenyl)ethyl］ Malonate

XU Zhibing¹, LU Haibin¹, LIANG Yongtao¹, LIANG Tie², WANG Ensi¹,³

1. College of Life Science, Jilin University, Changchun 130021, China; 2. The Affiliated Hospital, Changchun University of Chinese Medicine, Changchun 130061, China; 3. College of Pharmacy, Jilin University, Changchun 130021, China

Received:2007-04-17 Revised:1900-01-01 Online:2008-03-26 Published:2008-03-26
Contact: LIANG Tie

Abstract

Abstract: Intramolecular cyclization of diethyl 2-acetamido2-［2-(4-octylphenyl)ethyl］ malonate was carried out in the presence of polyphosphoric acid. The major products of the cyclization were 1tetralone derivative and oxazole derivative. The structures of the product molecules were confirmed by IR,¹H NMR,¹³C NMR, MS, 2D NMR and reduction, hydrolization reaction in our experiments respectively.

Key words: cyclization, 1-tetralone, oxazole, structure, 2D NMR

CLC Number:

O625.52

XU Zhibing, LU Haibin, LIANG Yongtao, LIANG Tie, WANG Ensi,. Cyclization of Diethyl 2-Acetamido2-［2-(4-octylphenyl)ethyl］ Malonate[J].J4, 2008, 46(02): 351-354.

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Cyclization of Diethyl 2-Acetamido2-［2-(4-octylphenyl)ethyl］ Malonate

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