mPEG-DhHP-6的合成及其改善缺血再灌注心脏损伤

Journal of Jilin University Science Edition ›› 2025, Vol. 63 ›› Issue (5): 1499-1504.

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Synthesis of mPEG-DhHP-6 and Its Improvement on Ischemia-Reperfusion Heart Injury

LU Tong¹， ZHANG Citong²， XU Tingshuang³， QI Chong³， SUN Le⁴， XUE Yao¹

1. College of Chemistry， Jilin University， Changchun 130012， China；
2. The Bethune Hospital of Stomatology, Jilin University, Changchun 130021, China；
3. Institute of Translational Medicine， The First Bethune Hospital of Jilin University, Changchun 130021， China；
4. Meihekou Centeral Hospital， The First Bethune Hospital of Jilin University， Tonghua 134000， Jilin Province, China

Received:2024-10-22 Online:2025-09-26 Published:2025-09-26

Abstract

Abstract: In order to increase relative molecular weight of deuterohaemin-β-AlaHisThrValGluLys (DhHP-6), we synthesized mPEG-DhHP-6 through PEGylation, and adjusted the volume ratio of dimethyl sulfoxide (DMSO) and phosphate buffered saline (PBS) to achieve a yield of around 95%. The stability and activity of of mPEG-DhHP-6 have been improved compared to DhHP-6. mPEG-DhHP-6 can significantly reduce the incidence and duration of ventricular tachycardia and ventricular fibrillation after ischemia-reperfusion in rats, and can be used to protect cardiovascular system.

Key words: PEGylation, , deuterohaemin-β-AlaHisThrValGluLys (DhHP-6), , myocardial ischemia-reperfusion

CLC Number:

O611.3

LU Tong, ZHANG Citong, XU Tingshuang, QI Chong, SUN Le, XUE Yao. Synthesis of mPEG-DhHP-6 and Its Improvement on Ischemia-Reperfusion Heart Injury[J].Journal of Jilin University Science Edition, 2025, 63(5): 1499-1504.

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Synthesis of mPEG-DhHP-6 and Its Improvement on Ischemia-Reperfusion Heart Injury

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