In order to overcome the disadvantage of traditional ECG(Electro Cardio Gram) monitoring system, which circuit structure is complex, the volume and weight is big, and is not easy to carry. A portable wireless ECG monitoring system was designed, which used the analog front-end SOC(System On Chip) chip ADS1298 as the core chip of ECG measurement, combined with high speed and low power consumption MCU STC12LE5A60S2, and a wireless transmission module. The ECG data was transmitted to the PC through wireless communication, in which the digital ECG signals was processed and displayed via an application software of LabVIEW. Results show that this system has some advantages such as simple circuit structure, small volume, strong anti-jamming capability, portable, high precision, etc. This system can play an important role in detecting and preventing pre-hospital cardiovascular disease, and reducing the incidences of sudden cardiac death.