Traditional application MIL-STD-1553B ( Military Standard 1553 Bus) data bus requires many peripheral chips. Based on the study of MIL-STD-1553 bus protocol, 1553B interface module and FPGA (Field Programmable Gate Array) are designed. I use transformer coupling, through HI-1567 converter, send the signal to the FPGA. And I use abundant logic resources in FPGA to complete the bus data gathering, encoding, decoding and communicate with the PC. And I comprehensively analyze the principles and processes of FPGA control 1553B bus. Then, I give specific method of FPGA control USB interface. Finally, FPGA received data is displayed on the PC. The experiment results show that the plan using FPGA to realize 1553B bus interface, reduces a lot of peripheral circuits, improves the reliability and real-time performance of the system, completes the bus data sending and receiving, achieves a lossless data transfer.