关键词: RET基因, 甲状腺肿瘤, 基因多态性

Abstract: Abstract:Objective To investigate the association between the gene polymorphisms of rs1799939 site of RET exon 11 and papillary thyroid carcinoma(PTC),and to provide theoretical basis for genetic mechanism of PTC.Methods A case-control 　study was used in this research.100 cases of PTC were selected as case group,100 healthy people matched in age and sex were selected as control group.PCR-RELP analysis was employed to detect the genotypes of the two groups，statistical analysis software SPSS 13.0 was used to analyze the association between the gene polymorphisms of rs1799939 site and PTC.Results The distribution of genotypic frequency of rs1799939 site didn’t deviate from Hardy-Weinberg equilibrium in both case group and control group (P>0.05).The distribution of genotypic and allelic frequencies at rs1799939 site showed no statistical significance between case group and control group (P>0.05).The distribution of genotypic and allelic frequencies between different genders in case group showed no statistical significance either (P>0.05).Conclusion The polymorphism of rs1799939 site in the RET gene may be not associated with the occurrence of PTC.

Key words: RET gene, thyroid neoplasms, genepolymorphism