Seventy-five rats were randomly divided into sham operation group， model group， dexamethasone group （positive control， given 2 mg·kg^－1 dexamethasone ）， low dose of PP Ⅶ group （given 50 mg·kg^－1 PP Ⅶ）， and high dose of PP Ⅶ group （given 150 mg·kg^－1 PP Ⅶ）， and there were 15 rats in each group. Except sham operation group，the SAP rat models were established by retrograde biliopancreatic tube injection of 5% sodium sulfonate solution in the rats in the other groups.The rats were immediately treated with the corresponding drugs. The arterial blood oxygenation index （OI） and wet weight/dry weight （W/D） ratio of lung tissue of the rats in various groups were measured. The levels of lipase and amylase in serum and the levels of interleukin1β （IL-1β），interleukin 6 （IL-6），andtumor necrosis factor（TNF-α）in bronchoalveolar lavage fluid （BALF） of the rats in various groups were detected by ELISA method； HE staining was used to observe the pathomophology of pancreas tissue and lung tissue of the rats in various groups，and the expression levels of nuclear factor-κB（NF-κB） signaling pathway related proteins in lung tissue of the rats in various groups were detected by Western blotting method.

Compared with sham operation group， the pancreas tissue and lung tissue of the rats in model group were severely damaged，the OI value of arterial blood was significantly decreased （P<0.01）， while the W/D ratio of lung tissue， levels of lipase and amylase in serum， levels of IL-1β， IL-6 and TNF-α in BALF， and the expression levels of inhibitor of nucler factor-κB α（IκBα） and phosphorylated NF-κB（p-NF-κB） p65（Ser536） proteins in lung tissue were significantly increased （P<0.01）. Compared with model group， the damage degree of pancreas tissue and lung tissue of the rats in dexamethasone group and high dose of PP Ⅶ group was significantly improved， the OI values of arterial blood were significantly increased （P<0.01）， and the W/D ratios of lung tissue， levels of lipase and amylase in serum，levels of IL-1β， IL-6 and TNF-α in BALF， and the expression levels of IκBα and p-NF-κB p65（Ser536） proteins in lung tissue were significantly decreased （P<0.01）.

PP Ⅶ may play a protective role in acute lung injury of the SAP rats by inhibiting the NF-κB signaling pathway.