炎症标志物在冠状动脉粥样硬化性心脏病诊断和治疗中应用的研究进展

doi:10.13481/j.1671-587X.20240434

Abstract

Abstract:

The inflammatory response runs through the entire process of the onset and progression of coronary atherosclerotic heart disease （CHD）； various inflammatory cells and inflammatory factors are involved， and to a certain extent， determine the stability of coronary atherosclerotic plaques and the progression of the disease. Lipoprotein（a）［Lp（a）］， C-reactive protein （CRP）， neutrophils， platelets， and monocytes participate in the inflammatory response through various mechanisms such as inducing inflammatory factors， stimulating inflammatory cells， and secreting active substances， thus promoting the atherosclerosis. In contrast， the lymphocytes， as important immune cells， serve as the indicators of anti-inflammation. High-density lipoprotein cholesterol （HDL-C） exerts its anti-atherosclerotic effects by reversing cholesterol transport and inhibiting the aggregation of the inflammatory cells. In recent years， novel inflammatory markers composed of the aforementioned inflammation-related indicators have been closely related to the onset and progression of CHD and have significant guiding value in the diagnosis， treatment， and prognosis of CHD. Reducing inflammation remains a hotspot in current CHD research. The study analyzes the mechanism of promoting the CHD development by new inflammatory markers and reviews the therapeutic advancements targeting these relevant inflammatory markers， and provides the basis for the diagnosis and treatment of CHD.

Key words: Atherosclerosis, Coronary heart disease, Inflammation, Marker

CLC Number:

R541.4

Xiaoyu WANG,Bing LI,Guohui LIU. Research progress in application of inflammatory markers in diagnosis and treatment of coronary heart disease[J].Journal of Jilin University(Medicine Edition), 2024, 50(4): 1173-1181.

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