Abstract: Objective To investigate the association between aldosterone synthase CYP11B2 (-344C/T)
gene polymorphism and ischemic stroke (IS) by Meta-analysis and to provide evide
nce for the treatment of IS.Methods Case-control studies on the association between CYP11B2 gene polymorphism and IS
 from  1990 to 2012 were collected from China national knowledge internet,Chinese biological medicine disk,Vip fulltext database,Wanfang fulltext database,PubMed and Cochrane Collaboration Database.Meta-analysis was carried out after strict screening.Heterogeneity test，sensitivity analysis and publication bias assessment were also performed.Results A total of 6 studies were included.In IS group,the pooled OR ( 95% CI ) of TT ／(TT + CC) genotype was 1.51( 1.06,2.16,P<0.05). In large artery atherosclerotic stroke LAA group,the pooled OR (95% CI ) of
TT/(TT + CC) genotype was 1.85(1.11,3.08,P<0.05).In multiple lacunar stroke (MLI) group,the pooled OR
(95% CI) of TT/ (TT + CC) genotype was 2.46(1.21,4.99,P<0.05).Conclusion The TT genotype of CYP11B2 gene is associated with IS,a
nd TT genotype is also associated with LAA and MLI,which indicats that CYP11B2 gene
is possiblely the candidate gene of IS.

Key words: CYP11B2 , ischemic stroke, gene polymorphism, Meta-analysis