Abstract:

Abstract:Objective To explore the intervention effect of  N-acetylglucosamine(GlcNAc) on injury of liver tissuesinduced by alcohol and clarify its mechanism. Methods Alcohol-induced liver disease model was established by feeding rats with white spirit bought in market. Meanwhile,intervention groups were set up by adding low,middle and high doses of GlcNAc tothe white spirit. Beginning drunken time and drunken duration were then compared between model group and intervention groups. Paraffin section of intestinal tracttissues tissues and liver tissues were used to observe the  pathological injury in model group and intervention groups with HEstaining. Results Compared with model group,the beginning drunken time was prolonged (P<0.05,P<0.01) and the drunkenduration was gradually shortened (P<0.05,P<0.01) in intervention groups.The  injury of intestinal mucosa structures in modelgroup could observed through paraffin section,the glands shrank    back,the exfoliative gut mucosa cells were found. Mostliver cell membranes were disrupted,a few nuclei were broken and disappeared,hepatic cell cord was filled with light-acidophilia and homogeneous matter and adjacent tissues were lossened. There was attenuation at different  degrees in all low middle and high doses of GlcNAc groups. Conclusion GlcNAc may relieve the injury of liver tissues and  ntestinaltracttissues induced by alcohol,and the protective effect of GlcNAc on liver may be associated with its function of stabilizing  the intestinal mucosal barrier.

Key words: alcohol;a-Acetylglucosaming;intestinal mucosa, permeability;hepatocytes/pathology