Abstract:

Objective To explore the effects of salmeterol/fluticasone propionate complicated or combined with N-acetylcysteine on the pulmonary function and  arterial blood gas analysis of the patients with chronic obstructive pulmonary disease(COPD)，and to evaluate its curative effect.Methods 84 cases of COPD patients were randomly divided into combination treatment group (n=44) and simple treatment group (n=40).The patients in combination treatment group were treated with
salmeterol/fluticasone propionate combinated with N-acetylcysteine while the patients in simple treatment group were treated only with salmeterol/fluticasone prop
ionate，both of which were followed up for 6 months.The changes of pulmonary function (FEV1%FVC,FEV1%Pred,PEF daily variation rate: Δ PEF%) and  theart
erial blood gas analysis indexes ( PaO₂ and PaCO₂ ) of the patients in two groups were recorded before treatment,3 months after treatment,and 6 months after treatment.Results The FEV1%FVC,FEV1%Pred and PaO2 of the patients in combinationtreatment group and simple treatment group were obviously increased 3 and 6 months after treatment compared with before treatment (P<0.01)，and the PaCO₂ were obviously decreased (P<0.01).And there were significant differences of the indexes mentioned above of the patients  between two groups(P<0.05)；but the indexes of each group had no significant differences between 3 months and 6 months after treatment(P>0.05).The Δ PEF% of the patients in two groups had no significant differences between inter-group and intra-group before and after treatment (P>0.05).Conclusion Combination of salmeterol/fluticasone propionate and N-acetylcysteine can obviously improve the pulmonary function and arterial blood gas analysis indexes  of the COPD patients,which is superior to the simple application of salmeterol/fluticasone propionate and has definite and lasting curative effect on the treatment of COPD.
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Key words: salmeterol/fluticasone propionate, N-acetylcysteine, chronic obstructive pulmonary disease, pulmonary function test, blood gas analysis