Abstract:

Abstract:Objective To detect the serum levels of carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125) and carcino-embryonic antigen(CEA) in different population， and to explore their significances in diagnosis of pancreaticcancer.Methods The serum levels of CA199,CA125 and CEA in 56 patients with pancreatic cancer(pancreatic cancer group),56 patients with benign pancreatic disease(benign pancreatic disease group) and 56 healthy volunteers（normalcontrol group）were detected,then the positive rates of CA199,CA125 and CEA and the sensitivities and specificities of CA199,CEA and CA125 for the diagnosis of pancreatic cancer were compared among three groups.Results The levels of serum CA199,CA125 and CEA of the patients in pancreatic cancer group were significantly higher than those in benign pancreatic disease group and normal control group (P<0.05).The positive rates of CA199,CEA and CA125  in pancreatic cancer group were 87.50 %,71.42%，  and 60.71%,respectively. The  positive rates of the three tumor markers of the patients in pancreatic cancer group were obviously higher than those in other two groups (P<0.05).The sensitivity of CA199（87.50%） was the highest,while the specificity of CEA （91.96%） was the higest.The method of parallel combined testing increased the diagnostic sensitivity to 95.12% and negative predictive value to 90.47%,but its specificity and the positive predictive value were decreased.Serial combined examination increased the diagnostic specificity to 92.86% and the positive predictive value to 89.19%,but its sensitivity and negative predictive value were decreased.Conclusion Combined detection of serum levels of CA199,CA125 and CEA has higher sensitivity and specificity than single-marker detection in the diagnosis of pancreatic cancer.

Key words: pancreatic neoplasms, tumor marker, glycoprotein antigen 199, glycoprotein antigen 125, carcino-embryonic antigen