The SiHa cells were randomly divided into control group， low dose of OMT group， medium dose of OMT group， and high dose of OMT group. The cells were cultured with RPMI 1640 medium containing dimethyl sulfoxide （DMSO）， 0.4， 0.8 and 1.6 g·L^－1 OMT. After 24 h of culture， the morphology of cells in various groups was detected by Hoechst33258 staining method； after 24， 48 and 72 h of culture， the proliferation activities of cells in various groups were detected by MTT method； after 48 h， the percentage of cells in different cell cycles and the apoptotic rates in various groups were detected by flow cytometry； RT-qPCR and Western blotting methods were used to detect the expression levels of β-catenin， cyclin D1， B-cell lymphoma-2 （Bcl-2）， Bcl-2 assaciated X protein （Bax） mRNA and proteins.

Under fluorescence microscope， the cells in control group grew well， and the blue fluorescence was weak； a small amount of apoptotic bodies were seen in low dose of OMT group； the number of cells in medium dose of OMT group was decreased， and the number of apoptotic bodies were increased； the blue fluorescence in high dose of OMT group was increased， cell disintegration and nuclear shrinkage were found， and the number of apoptotic bodies were increased significantly. Compared with control group， at 24， 48， and 72 h after culture，the proliferation activities of the cells in low dose of OMT group， medium dose of OMTgroup and high dose of OMT group were decreased significantly （P<0.05）， the percentage of cells in G₀/G₁ phase were increased（P<0.05）， the percentages of cells in S and G₂/M phases were decreased （P<0.05）， the apoptotic rates of cells were increased（P<0.05），the expression levels of β-catenin， cyclinD1， Bcl-2 mRNA and proteins were decreased（P<0.05），and the expression levels of Bax mRNA and protein were increased（P<0.05）.

OMT can block the SiHa cells in the G₁ phase，and inhibit the cell proliferation and induce the apoptosis；its machanism may be related to the inhibition of Wnt/β-catenin signaling pathway.