Abstract:

Objective To analyze the levels of serum soluble intercellular adhesion molecule-1 （sICAM-1）， soluble vascular cell adhesion molecule-1 （sVCAM-1）， and superoxide dismutase （SOD） activity in the patients with maintenance hemodialysis （MHD）， and to discuss their relationships with coronary artery calcification （CAC）. Methods The clinical materials from 102 MHD patients （MHD group） were retrospectively analyzed. Additionally， 74 volunteers underwent routine health examination at the same time （health examination group） were selected. The CAC scores （CACs） of the patients in MHD group were detected by multi-slice computed tomography （MSCT）， and the patients were categorized into non-calcification group， mild calcification group， moderate calcification group， and severe calcification group. The general data and serum levels of sICAM-1， sVCAM-1， and SOD activities of the subjects in two groups were compared. The levels of calcium （Ca）， phosphorus （P）， parathyroid hormone （PTH）， sICAM-1， sVCAM-1， and SOD activities in serum of the patients with different degrees of calcification were analyzed. Pearson’s correlation analysis was used to analyze the correlations between the levels of sICAM-1， sVCAM-1， and SOD activity in serum of the MHD patients and CACs. Results Compared with health examination group， the levels of sICAM-1 and sVCAM-1 in serum of the patients in MHD group were significantly increased （P<0.01）， and the SOD activity was significantly decreased （P<0.01）. Compared with non-calcification group， the levels of PTH， sICAM-1， and sVCAM-1 in serum of the MHD patients in mild， moderate， and severe calcification groups were significantly increased （P<0.05）， and the SOD activities were significantly decreased （P<0.05）； the levels of P in serum of the MHD patients in moderate and severe calcification groups were significantly increased （P<0.05）. Compared with mild calcification group， the levels of P， PTH， sICAM-1， and sVCAM-1 in serum of the MHD patients in moderate and severe calcification groups were significantly increased （P<0.05）， and the SOD activities significantly decreased （P<0.05）. Compared with moderate calcification group， the levels of sICAM-1， sVCAM-1， and P in serum of the MHD patients in severe calcification group were significantly increased （P<0.05）， and the SOD activity was significantly decreased （P<0.05）. The SOD activity in serum of the MHD patients was negatively correlated with CACs （r =-0.484， P<0.01）， while the levels of sICAM-1 and sVCAM-1 were positively correlated with CACs （r =0.441， P<0.01； r = 0.561， P<0.01）. Conclusion The levels of sICAM-1 and sVCAM-1 and activity of SOD in serum of the MHD patients are abnormal. With the decreasing of the SOD activity and increasing of the levels of sICAM-1 and sVCAM-1， the degree of CAC in the MHD patients is aggravated.

Key words: Maintenance hemodialysis, Superoxide dismutase, Soluble intercellular adhesion molecule-1, Soluble vascular cell adhesion molecule-1, Coronary artery calcification