A passenger car tire 205/55R16 is taken as the research object, and the relationship between tire force transmissibility and tire cavity resonance noise is studied through experiments. It is proposed that the amplitude of tire force transmissibility has the ability of representing the level of tire resonance cavity noise. A tire force transmissibility simulation model with sound-absorbing material is established using finite element method, and it is found that the mechanical parameters of porous sound-absorbing material have more significant influence on the noise reduction effect than the sound absorption coefficient. The optimal Latin hypercube test method and the Kriging approximate model are selected to explore the influences of the density, elastic modulus, width and thickness of the porous material's on the amplitude of the tire force transmissibility, and the multi-island genetic optimization algorithm is chosen to optimize the above four parameters of the porous material. By changing the single width parameter of the porous material, the accuracy of the simulation results is verified through the tire force transmission test and the falling noise test. The results show that compared with the original tire, the amplitude of tire force transmissibility of the optimized tire is significantly reduced, and the cavity resonance noise of the tire is also effectively improved.