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1-甲基海因的合成及其晶体结构分析

王永生1,2, 杨桠楠1, 李亚巍1, 李桂英1   

  1. 1. 吉林大学 药学院, 长春 130021; 2. 长春中医药大学 中医药与生物工程研究开发中心, 长春 130021
  • 收稿日期:2006-11-28 修回日期:1900-01-01 出版日期:2007-07-26 发布日期:2007-07-26
  • 通讯作者: 李桂英

Synthesis of 1Methylhydantoin and Its Crystal Structure

WANG Yongsheng1,2, YANG Yanan1, LI Yawei1, LI Guiying1   

  1. 1. College of Pharmacy, Jilin University, Changchun 130021, China ; 2. Center for the Study of Chinese Medicine and Bio\|engineering, Changchun University of Chinese Medicine, Changchun 130021, China
  • Received:2006-11-28 Revised:1900-01-01 Online:2007-07-26 Published:2007-07-26
  • Contact: LI Guiying

摘要: 以甲胺、 氯乙酸钠、 氰酸钠等为原料, 用“一锅法”合成1-甲基海因, 合成总收率为62.9%.单晶经X射线衍射方法解析, 其晶体属于单斜 晶系, P21空间群, 其中a=0.558 9(3) nm, b=1.217 6(6) nm, c=0.809 0(4) nm;β=105.330(7)°;V=0.531 0(5) nm3;Z=4, Dc=1.427 mg/m3, μ=0.116 mm-1, F(000)=240.

关键词: 1-甲基海因, 合成, 晶体结构

Abstract: 1-Methylhydantoin was synthesized from the reaction of methylamine, sodium monochloroacetate and sodium cyanate by “one pot” method with a total yield of 62.9%. 1Methylhydantoin was characterized by means of single crystal Xray diffraction. It crystallized in the monoclinic space group P21 with crystallgraphic parameters: a=0.558 9(3) nm, b=1.217 6(6) nm, c=0.809 0(4) nm;β=105.330(7)°;V=0.531 0(5) nm3;Z=4, Dc=1.427 mg/m3, μ=0.116 mm-1, F(000)=240.

Key words: synthesis, 1-Methylhydantoin, crystal structure

中图分类号: 

  • O626