一步法合成多取代2-氨基噻酚衍生物

一步法合成多取代2-氨基噻酚衍生物

刘丽¹, 李政¹, 李洪斌¹, 陆航¹, 丁长江¹, 董德文²

1. 吉林大学化学学院, 长春 130021; 2. 中国科学院长春应用化学研究所，长春 130022

收稿日期:2007-01-04 修回日期:1900-01-01 出版日期:2007-09-26 发布日期:2007-09-26
通讯作者: 丁长江

Onepot Synthesis of Polysubstituted 2Amino Thiophenes

LIU Li¹, LI Zheng¹, LI Hongbin¹, LU Hang¹, DING Changjiang¹, DONG De wen²

1. College of Chemistry, Jilin University, Changchun 130021, China;2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received:2007-01-04 Revised:1900-01-01 Online:2007-09-26 Published:2007-09-26
Contact: DING Changjiang

摘要/Abstract

摘要： 在碳酸钾作用下, 采用乙酰乙酰胺类化合物与苯硫代异氰酸酯、溴代乙酸乙酯在N,N-二甲基甲酰胺中反应, 合成了多取代2-氨基噻酚衍生物, 通过核磁共振、红外光谱及元素分析方法对产物进行表征, 并对该反应机理进行初步探讨.

关键词: 乙酰乙酰胺化合物, 苯硫代异氰酸酯, 2-氨基噻酚衍生物, 成环反应

Abstract: Polysubstituted 2-aminothiophenes were onepot-synthesized from β-oxo amides with 1-isothiocyanatobenzeneand ethyl 2-bro moacetate in the presence of K_{2_{CO_{3_{in N,N-dimethylformamide (DMF) in very high yield. The products were characterized by means of NMR, IR and elemental analysis. Moreover, a mechanism for the reaction was proposed.}}}}

Key words: 1-isothiocyanatobenzene, 2-aminothiophenes, cyclization reaction

中图分类号:

O626.12

刘丽, 李政, 李洪斌, 陆航, 丁长江, 董德文. 一步法合成多取代2-氨基噻酚衍生物[J]. J4, 2007, 45(05): 853-856.

LIU Li, LI Zheng, LI Hongbin, LU Hang, DING Changjiang, DONG De wen. Onepot Synthesis of Polysubstituted 2Amino Thiophenes[J]. J4, 2007, 45(05): 853-856.