亮菌甲素在大鼠体内的绝对生物利用度

亮菌甲素在大鼠体内的绝对生物利用度

王岩¹,², 王中华², 刘明远³, 董雷¹, 顾景凯²

1. 吉林大学第一医院药剂科, 长春 130021； 2. 吉林大学生命科学学院, 长春 130021;3. 佳木斯大学基础医学院, 黑龙江佳木斯 154007

收稿日期:2007-06-10 修回日期:1900-01-01 出版日期:2008-01-26 发布日期:2008-01-26
通讯作者: 顾景凯

Absolute Bioavailability of Armillarisin A in Rats

WANG Yan¹,², WANG Zhonghua², LIU Mingyuan³, DONG Lei¹, GU Jingkai²

1. Department of Medication, First Hospital, Jilin University, Changchun 130021, China；2. College of Life Science, Jilin University, Changchun 130021, China;3. School of Basic Medical Sciences, Jiamusi University, Jiamusi 154007, Heilongjiang Province, China

Received:2007-06-10 Revised:1900-01-01 Online:2008-01-26 Published:2008-01-26
Contact: GU Jingkai

摘要/Abstract

摘要： 采用液相色谱串联质谱（LC-MS/MS）法测定大鼠血浆中亮菌甲素的浓度, 研究亮菌甲素在大鼠体内药动学特征及其绝对生物利用度. 结果表明, 亮菌甲素灌胃给药(ig)1.44 mg和静脉注射给药(iv)0.9 mg后, 在大鼠体内的主要药动学参数达峰浓度(cmax)分别为(58.33±23.41),(825.25±92.13) μg/L, 半衰期(t_1/2)分别为(1.55±0.43), (0.75±035) h, 血药浓度-时间曲线下面积(AUC_0~t)分别为(41.87±7.54), (140.64±19.73) h·(μg/L). 经剂量校正后求得亮菌甲素在大鼠体内的绝对生物利用度(F_ab)为18.61%.

关键词: 亮菌甲素, 药代动力学, 绝对生物利用度

Abstract: To investigate the pharmacokinetic characteristics of Armillarisin A and its absolute bioavailability in rats, 1.44 mg and 0.9 mg of Armillarisin A were given via ig and iv to SD rats, respectively; the plasma concentration of Armillarisin A in rats was determined by LCMS/MS. After ig administration of Armillarisin A, the main pharmacokinetic parameters c_max, t_1/2, AUC_0~t were (58.33±23.41) μg/L, (155±043) h, (4187±754) h·(μg/L), respectively; After iv administration of Armillarisin A, the major pharmacokinetic parameters c_max, t_1/2, AUC_0~t were (825.25±92.13) μg/L, (0.75±0.35) h, (140.64±19.73) h·(μg/L), respectively. The absolute bioavailability was 18.61% after correction of dosage.

Key words: Armillarisin A, pharmacokinetics, absolute bioavailability

中图分类号:

R969.1

王岩,, 王中华, 刘明远, 董雷, 顾景凯. 亮菌甲素在大鼠体内的绝对生物利用度[J]. J4, 2008, 46(01): 154-156.

WANG Yan,, WANG Zhonghua, LIU Mingyuan, DONG Lei, GU Jingkai. Absolute Bioavailability of Armillarisin A in Rats[J]. J4, 2008, 46(01): 154-156.

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