酶法手性拆分技术研究和应用的最新进展

酶法手性拆分技术研究和应用的最新进展

张国艳¹,², 曹淑桂¹

1. 吉林大学分子酶学工程教育部重点实验室, 长春 130021; 2. 吉林大学化学学院, 长春 130021

收稿日期:2007-09-14 修回日期:1900-01-01 出版日期:2008-09-26 发布日期:2008-09-26
通讯作者: 张国艳

The Newly Development of theEnzymecatalyzed Resolution Methods and Application

ZHANG Guoyan¹,², CAO Shugui¹

1. Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, Jilin University,Changchun 130021, China; 2. College of Chemistry, Jilin University, Changchun 130021, China

Received:2007-09-14 Revised:1900-01-01 Online:2008-09-26 Published:2008-09-26
Contact: ZHANG Guoyan

摘要/Abstract

摘要： 系统地综述了酶法手性拆分技术的最新研究和应用进展，对动力学拆分、动态动力学拆分和对映体收敛转化3种方法进行了比较，并介绍了酶，尤其是脂肪酶在非水介质中催化酯和氨基化合物的立体选择性水解、转酯化和酰胺化的研究进展及其在技术上遇到的问题和解决方法.

关键词: 手性拆分, 动力学拆分, 动态动力学拆分, 对映体收敛转化

Abstract: The present paper described the recent research and application of chiral resolution by enzyme {catalysis}. The methods of kinetic resolution, dynamic kinetic resolution and enantioconvergence resolution were compared with each other. The steoroselective hydrolysis, transesterification and acylation of esters and amines catalyzed by enzymes, in particular, hydrolases in non-aqueous solution were also introduced {according} to the progress of research and the problems of technology.

Key words: chiral resolution, kinetic resolution, dynamic kinetic resolution, enantioconvergence

中图分类号:

Q814

张国艳,, 曹淑桂. 酶法手性拆分技术研究和应用的最新进展[J]. J4, 2008, 46(05): 997-1000.

ZHANG Guoyan,, CAO Shugui. The Newly Development of theEnzymecatalyzed Resolution Methods and Application[J]. J4, 2008, 46(05): 997-1000.

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