中空介孔二氧化硅纳米材料(HMSNs)的合成及其生物相容性

吉林大学学报(理学版)

中空介孔二氧化硅纳米材料(HMSNs)的合成及其生物相容性

郑昆^1, 杨红^2, 温刚^1, 张元新^1, 葛雅琨^1, 隋新¹

1. 吉林化工学院生物与食品工程学院, 吉林吉林 132022; 2. 吉林工贸学校, 吉林吉林 132021

收稿日期:2015-05-25 出版日期:2016-01-26 发布日期:2016-01-19
通讯作者: 郑昆 E-mail:kunzheng16@aliyun.com

Synthesis of Hollow Mesoporous Silica Nanoparticlesand Its Biocompatibility

ZHENG Kun^1, YANG Hong^2, WEN Gang^1, ZHANG Yuanxin^1, GE Yakun^1, SUI Xin^1

1. College of Biology and Food Engineering, Jilin Institute of Chemical Technology, Jilin 132022, Jilin Province, China； 2. Jilin Industry and Trade School, Jilin 132021, Jilin Province, China

Received:2015-05-25 Online:2016-01-26 Published:2016-01-19
Contact: ZHENG Kun E-mail:kunzheng16@aliyun.com

摘要/Abstract

摘要：

以CaCO₃为模板合成中空介孔二氧化硅纳米材料（HMSNs）, 并通过透射电镜（TEM）和小角X射线粉末衍射（SAXRD）对样品进行表征, 通过流式
细胞仪检测HMSNs样品对A549的细胞内吞能力及生物相容性. 结果表明: CaCO₃HMSNs是以CaCO₃为核，介孔二氧化硅为壳的纳米粒子; 当材料的质量浓度为62.5 μg/mL时, 细胞的存活率为100%；有92.80%的细胞吸收了样品HMSNs, 即HMSNs具有较高的细胞内吞能力及生物相容性.

关键词: 中空介孔二氧化硅纳米材料, 生物相容性, 细胞内吞作用

Abstract:

We used CaCO₃ as a template to synthesize hollow mesoporous silica nanoparticles (HMSNs), and characterized the samples by means of transmission electron microscope (TEM) and small angle Xray diffraction (SAXRD). The in vitro biocompatibility and endocytosis properties of HMSNs were detected on A549 cells by flow cytometry. The results show that CaCO_3HMSNs is the nanopartocles, where CaCO₃ is the core and mesoporous silica is the shell; the survival rate of the cells is 100% when the mass concentration of HMSNs is 62.5 μg/mL; the HMSNs materials are absorbed by 92.80% of A549. That is, the HMSNs has a higher endocytosis and biocompatibility.

Key words: hollow mesoporous silica nanoparticles (HMSNs), biocompatibility, endocytosis

中图分类号:

O613.72

郑昆, 杨红, 温刚, 张元新, 葛雅琨, 隋新. 中空介孔二氧化硅纳米材料(HMSNs)的合成及其生物相容性[J]. 吉林大学学报(理学版), 2016, 54(01): 148-151.

ZHENG Kun, YANG Hong, WEN Gang, ZHANG Yuanxin, GE Yakun, SUI Xin. Synthesis of Hollow Mesoporous Silica Nanoparticlesand Its Biocompatibility[J]. Journal of Jilin University Science Edition, 2016, 54(01): 148-151.