吉林大学学报(理学版)

• 生命科学 • 上一篇    下一篇

以秀丽隐杆线虫为模型的玛咖功效评价

王丽萍1, 张丽梅2, 侯思远2, 徐佳1, 隋天卓1, 张瑞宁1, 王琪菲3, 王立成3   

  1. 1. 吉林大学 生命科学学院, 长春 130012; 2. 新时代健康产业(集团)有限公司, 北京102206; 3. 吉林大学 化学学院, 长春 130012
  • 收稿日期:2017-06-01 出版日期:2018-03-26 发布日期:2018-03-27
  • 通讯作者: 王立成 E-mail:wanglc@jlu.edu.cn

Efficacy Evaluation of Maca Using Caenorhabditis elegans as a Model

WANG Liping1, ZHANG Limei2, HOU Siyuan2, XU Jia1, SUI Tianzhuo1,ZHANG Ruining1, WANG Qifei3, WANG Licheng3   

  1. 1. College of Life Science, Jilin University, Changchun 130012, China;2. New Era Health Industry (Group) Co., Ltd., Beijing 102206, China;3. College of Chemistry, Jilin University, Changchun 130012, China
  • Received:2017-06-01 Online:2018-03-26 Published:2018-03-27
  • Contact: WANG Licheng E-mail:wanglc@jlu.edu.cn

摘要: 先对玛咖进行脱油、 水提、 冻干, 再将所得水提物冻干品与Escherichia coli OP50菌液进行混合, 稀释至终质量浓度为1,2 mg/mL. 以秀丽隐杆线虫(简称线虫)为模型, 考察玛咖水提物对线虫的抗氧化作用: 经寿命、 产卵、 吞咽、 运动能力实验表明, 玛咖水提物对线虫无明显毒性作用, 且1,2 mg/mL玛咖水提物均能显著延长线虫寿命; 由玛咖水提物对线虫热激氧化压力诱导表明, 玛咖水提物对线虫体外热激氧化压力有保护作用; 通过油红O对脂肪染色表明, 玛咖水提物具有一定降脂功效.

关键词: 抗氧化剂, 玛咖, 降脂, 秀丽隐杆线虫

Abstract: Maca was extracted by oil removing, water extraction and lyophilized. The water extract was mixed with Escherichia coli OP50 broth and diluted to a final mass concentration of 1,2 mg/mL. The antioxidation effect of water extract of Maca on Caenorhabditis elegans was studied with C.elegans as a model. The experiments of lifespan, spawning, swallowing and motor ability show that the water extract of Maca has no obvious toxic effect on nematodes, and 1,2 mg/mL water extract of Maca can significantly prolong the lifespan of nematodes. The water extract of Maca has protective effect on nematode induced by oxidative stress. The oil red O staining shows that the water extract of Maca has a certain effect on lipidlowering.

Key words: lipidlowering, Caenorhabditis elegans, Maca, antioxidant

中图分类号: 

  • Q946