口服降糖药曲格列酮的核磁共振谱学表征

口服降糖药曲格列酮的核磁共振谱学表征

尹建元^1,,王恩思^1,2

1.吉林大学药学院,长春,130021; 2.吉林大学生命科学学院,长春,130023

收稿日期:2002-05-28 修回日期:1900-01-01
通讯作者: 王恩思

Nuclear Magnetic Resonance Characterization of Oral Hypoglycemic Drug Troglitazone

YIN Jian-yuan¹,WANG En-si^1,2

1. College of Pharmacy , Jilin University , Changchun 130021 , China ;2. College of Life Science , Jilin University , Changchun 130023 , China

Received:2002-05-28 Revised:1900-01-01
Contact: WANG En-si

摘要/Abstract

摘要： 利用NMR,IR,UV及MS等实验技术研究了胰岛素增敏剂曲格列酮的波谱学特征.结合DEPT谱及1H-1H COSY 13C-1H HETCOSY,13C-1H LC-HETCOSY对曲格列酮的氢谱和碳谱进行完全归属.

关键词: 抗糖尿病药物, 曲格列酮, 核磁共振

Abstract: The NMR spectra are reported for troglitazone (5-[[4-[(6-hydroxy-2 ,5 ,7 ,8-tetramethyl-3 ,4-dihydrobenzopyran-2-yl-) methoxy ] pheny1 ] methy1] 2,4-thiazolidinedione) that is used as an oral hypoglycemic drug. By using DEPT , ¹H-¹H COSY , ¹³C-¹H HETCOSY and ¹³C-¹H LC-HETCOSY techniques along with IR , UV and MS , the proton and ¹³C spectra of troglitazone are assigned completely. This result also provides a basis analysis for the NMR characterization of the similar new drugs.

Key words: hypoglycemic drug, troglitazone, nuclear magnetic resonance

中图分类号:

O656.4

尹建元,王恩思. 口服降糖药曲格列酮的核磁共振谱学表征[J]. J4, 2002, 40(04): 423-425.

YIN Jian-yuan,WANG En-si. Nuclear Magnetic Resonance Characterization of Oral Hypoglycemic Drug Troglitazone[J]. J4, 2002, 40(04): 423-425.

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