松杉灵芝多糖的抗突变作用

松杉灵芝多糖的抗突变作用

郑克岩¹, 张洁⁴, 林相友², 李芳亮², 由宇润³, 费晓方²

1. 吉林大学公共化学教学与研究中心, 长春 130023; 2. 吉林大学生命科学学院生物制药系, 长春 130023; 3. 国家新药沈阳安全评价研究中心, 沈阳 110021;4. 长春中医学院药学院, 长春 130117

收稿日期:2004-07-13 修回日期:1900-01-01 出版日期:2005-03-26 发布日期:2005-03-26
通讯作者: 费晓方

Anti-mutagenic Effects of Polysaccharides from Ganoderma Tsugae

ZHENG Ke-yan¹, ZHANG Jie⁴, LIN Xiang-you²,LI Fang-liang², YOU Yu-run³, FEI Xiao-fang²

1. Teaching and Research Center of Chemistry, Jilin University, Changchun 130023, China;2. Department of Biology Pharmaceutics, College of Life Sciences, Jilin University, Changchun 130023, China; 3. National New Drug Safety Estimate Center, Shenyang 110021, China; 4. College of Pharmaceutics, Changchun College of Traditional Chinese Medicine, Changchun 130117, China

Received:2004-07-13 Revised:1900-01-01 Online:2005-03-26 Published:2005-03-26
Contact: FEI Xiao-fang

摘要/Abstract

摘要： 通过小鼠骨髓细胞微核试验、小鼠睾丸染色体畸变和Ames 试验观察了松杉灵芝多糖的抗突变作用. 结果表明，松杉灵芝多糖对TA98, TA100两株试验菌株，加与不加S-9均对阳性物致突变作用有抑制作用；口服不同剂量的药液30 d，能明显拮抗环磷酰胺所致小鼠骨髓细胞微核率，但对于丝裂霉素C诱发小鼠睾丸染色体畸变无明显抑制作用.

关键词: 松杉灵芝多糖, 抗突变, 畸变

Abstract: The anti-mutagenic effects of polysaccharides from Ganoderma tsugae were studied by mice bone marrow cell micronuclei test, mice testicular chromosome aberration test and Ames test. The micronuclei frequency induced by cyclophosphamide in mouse bone marrow cells was inhibited significantly, but mouse testicular chromosome aberration frequency induced by mitomycinc was not inhibited markedly by polysaccharides from Ganoderma tsugae. The Ames test showed that polysaccharides from Ganoderma tsugae have effectively anti-mutageni activties.

Key words: polysaccharides from Ganoderma tsugae, anti-mutagenic, aberration

中图分类号:

R392.11

郑克岩, 张洁, 林相友, 李芳亮, 由宇润, 费晓方. 松杉灵芝多糖的抗突变作用[J]. J4, 2005, 43(02): 235-237.

ZHENG Ke-yan, ZHANG Jie, LIN Xiang-you,LI Fang-liang, YOU Yu-run, FEI Xiao-fang. Anti-mutagenic Effects of Polysaccharides from Ganoderma Tsugae[J]. J4, 2005, 43(02): 235-237.

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