关键词: 复方左卡尼汀, 秀丽新杆线虫, 寿命, 生殖能力

Abstract:

Taking Caenorhabditis elegans worm as a model organism, we examined the effects of L-carnitine, trimetazidine, compound L-carnitine on the lifespan and reproductivity of the worms. Our results show that w(L-carnitine)=01%, w(trimetazidine)=0000 5% and compound L-carnitine did not change the lifespan of C. elegans. On the other hand, w(L-carnitine)=01%, w(trimetazidine)=0000 5%  significantly reduced the brood size in parental generation, F1 and F2. However, compound Lcarnitine has no effect on the reproductivity of the worms. Worms undergoing DR utilize fat, and diminish reproductive output. That is to say, the worms with restricteddietary intake have reduced broods. Our results indicate that w(L-carnitine)=01% and  w(trimetazidine)=0000 5% reduce both fat accumulation and overall fatty acid. However, compound L-carnitine has no effect on the overall fat and fat acid.

Key words: compound L-carnitine, Caenorhabditis elegans, lifespan, reproductivity