7-取代-2-氨基-1,2,3,4-四氢-2-萘甲酸的合成

J4 ›› 2010, Vol. 48 ›› Issue (05): 860-864.

7-取代-2-氨基-1,2,3,4-四氢-2-萘甲酸的合成

崔琳琳¹, 张群利^1,2, 米浩宇¹, 王恩思^1,3

1. 吉林大学生命科学学院, 长春 130021； 2. 东北林业大学包装工程系, 哈尔滨 150040;3. 吉林大学药学院, 长春 130021

收稿日期:2010-02-24 出版日期:2010-09-26 发布日期:2010-09-21
通讯作者: 王恩思 E-mail:wangss@jlu.edu.cn

Synthesis of 7-Substituted-2-amino-1,2,3,4-tetrahydro-2-naphthalene Carboxylic Acid

CUI Linlin¹, ZHANG Qunli^1,2, MI Haoyu¹, WANG Ensi^1,3

1. College of Life Science, Jilin University, Changchun 130021, China|2. Department of Packaging Engineering, Northeast Forestry University, Harbin 150040, China;3. College of Pharmacy, Jilin University, Changchun 130021, China

Received:2010-02-24 Online:2010-09-26 Published:2010-09-21
Contact: WANG Ensi E-mail:wangss@jlu.edu.cn

摘要/Abstract

摘要：

以7-取代苯乙酸为原料, 经由2-四氢萘酮中间体, 海因水解为关键步骤合成7-取代-2-氨基-1,2,3,4-四氢-2-萘甲酸, 总收率为32%, 并考察了不同7-取代海因的水解条件. 关键中间体及目标分子的结构经核磁共振氢谱、碳谱得到确认.

关键词: 7-取代-2-氨基-1,2,3,4-四氢-2-萘甲酸；合成；海因；水解

Abstract:

7-Substituted-2-amino-1,2,3,4-tetrahydro-2-naphthalene carboxylic acid was synthesized through 2tetralone intermediate by hyda
ntoin hydrolysis from the starting materials 7-substituted phenylacetic acid in a total yield of 32%, and hydrolysis conditions of different 7-substituted hydantoin were examined. The structures of the key intermediate and the target mole
cule were confirmed by ¹H NMR and ¹³C NMR.

Key words: 7-substituted-2-amino-1,2,3,4-tetrahydro-2-naphthalene carboxylic acid, synthesis, hydantoin, hydrolysis

中图分类号:

O656.4

崔琳琳, 张群利, 米浩宇, 王恩思. 7-取代-2-氨基-1,2,3,4-四氢-2-萘甲酸的合成[J]. J4, 2010, 48(05): 860-864.

CUI Lin-Lin, ZHANG Qun-Li, MI Gao-Yu, WANG En-Sai. Synthesis of 7-Substituted-2-amino-1,2,3,4-tetrahydro-2-naphthalene Carboxylic Acid[J]. J4, 2010, 48(05): 860-864.