关键词: 组学数据, 单样本网络, 注意力机制, 图注意力网络

Abstract: Aiming at the high-dimensional “big p small n” problem where the number of genes in biomics data (denoted as p) was far more than the number of samples (denoted as n), we proposd a graph attention network GATOr with local and global attention mechanisms. Firstly, the model used Pearson correlation coefficient to calculate the correlation between features on the omic data, and constructed a single sample network of the omic data. Secondly, we proposed a graph attention network which combined local and global attention mechanisms to learn graph-based omics feature representation from a single-sample network, thereby transforming the high-dimensional characteristics of the omics data into low-dimensional representations. The experimental results show that compared with other traditional classification algorithms, GATOr achieves better performance in classification task accuracy and other indexes.

Key words: omic data, single-sample network, attention mechanism, graph attention network