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YIN Jian-yuan1,WANG En-si1,2
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Abstract: The NMR spectra are reported for troglitazone (5-[[4-[(6-hydroxy-2 ,5 ,7 ,8-tetramethyl-3 ,4-dihydrobenzopyran-2-yl-) methoxy ] pheny1 ] methy1] 2,4-thiazolidinedione) that is used as an oral hypoglycemic drug. By using DEPT , 1H-1H COSY , 13C-1H HETCOSY and 13C-1H LC-HETCOSY techniques along with IR , UV and MS , the proton and 13C spectra of troglitazone are assigned completely. This result also provides a basis analysis for the NMR characterization of the similar new drugs.
Key words: hypoglycemic drug, troglitazone, nuclear magnetic resonance
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YIN Jian-yuan,WANG En-si. Nuclear Magnetic Resonance Characterization of Oral Hypoglycemic Drug Troglitazone[J].J4, 2002, 40(04): 423-425.
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URL: http://xuebao.jlu.edu.cn/lxb/EN/
http://xuebao.jlu.edu.cn/lxb/EN/Y2002/V40/I04/423
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