Abstract: In this paper, RGD(Arg-Gly-Asp) liposome formulation as a drug carrier was conducted. A film-ultrasonic technique was chosen for pr eparation of liposome. The observation by electron microscope indicated that the particle diameter of liposome was basically homogenous, being about 100 nm and small vesicles. The content of RGD in liposome is 2.4～2.5 mg/mL with the entrapment efficiency of 70%. RGD liposome prepared by the method used has not only better stability, but also target tropism at pH 5.4～6.0. Therefore, the prepared liposome here may become a kind of RGD formulation with better target tropism to tumor.

Key words: RGD, inhibition of tumor metastasis, liposome, targeted delivery