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Chemical Synthesis of Acetyl-L-carnitine and Its Enzymatic Resolution

DING Tian-bing1, WANG Zhi1, WENG Liang1, YU Da- hai1, ZHENG Liang-yu1, CAO Shu-gui1, GOU Xiao-jun2   

  1. 1. Key Laboratory for Molecular Enzymology and Engineering of Educational Ministry, Jilin University, Changchun 130023, China; 2. Department of Biolgical Engineering, Chengdu University, Chengdu 610106, China
  • Received:2003-01-06 Revised:1900-01-01 Online:2003-07-26 Published:2003-07-26
  • Contact: CAO Shu-gui

Abstract: Acetyl-L-carnitine was synthesized from racemic carnitine chloride and acetic acid by chemical means. The purity of the refined product was over 99% a nd the yield was about 96%. Acetyl-L-carnitine with 98% ee was obtained by Snail enzyme catalyzing the resolution of racemic acetyl carnitine.

Key words: acetyl-carnitine, chemical synthesis, Snail enzyme, resolution

CLC Number: 

  • Q55