血浆p16基因甲基化在原发性肝细胞癌诊断中的作用

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Methylation of p16 gene in plasma in diagnosis of primary hepatocellular carcinoma

LUO Su^1,2， ZHANG Feng-chun¹， LIU Cheng-bai³, WANG Xiao¹, ZHUANG Jiang-xing^3,4， ZHANG Jin²

1. Medical College of Beihua University, Jilin 132013, China;2. Key Laboratory of Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun 130023, China; 3. College of Life Science, Jilin University, Changchun 130023, China; 4. Fujian Zhangzhou Institute of Drug Control, Zhangzhou 363000, China

Received:2003-12-05 Revised:1900-01-01 Online:2004-04-26 Published:2004-04-26
Contact: LUO Su

Abstract

Abstract: Using the methylation specific PCR(MSP) to detect the methylation of p16 geng of each of 30 patients with primary hepatocellular carcinoma(HCC), 30 patients with cirrhosis, 30 patients with chronic hepatitis and 30 healthy individ uals, respectively. The results show that the methylation of p16 gene was foun ded in 20 of the 30 patients (67%) with primary hepatocellular carcinoma. In the other groups was without the methylation of p16 gene.

Key words: primary hepatocellular carcinoma, p16 gene, methylation

CLC Number:

Q953

LUO Su， ZHANG Feng-chun， LIU Cheng-bai, WANG Xiao, ZHUANG Jiang-xing， ZHANG Jin. Methylation of p16 gene in plasma in diagnosis of primary hepatocellular carcinoma[J].J4, 2004, 42(02): 298-301.

Methylation of p16 gene in plasma in diagnosis of primary hepatocellular carcinoma

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