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Onepot Synthesis of Polysubstituted 2Amino Thiophenes

LIU Li1, LI Zheng1, LI Hongbin1, LU Hang1, DING Changjiang1, DONG De wen2   

  1. 1. College of Chemistry, Jilin University, Changchun 130021, China;2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2007-01-04 Revised:1900-01-01 Online:2007-09-26 Published:2007-09-26
  • Contact: DING Changjiang

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Abstract: Polysubstituted 2-aminothiophenes were onepot-synthesized from β-oxo amides with 1-isothiocyanatobenzeneand ethyl 2-bro moacetate in the presence of K2CO3 in N,N-dimethylformamide (DMF) in very high yield. The products were characterized by means of NMR, IR and elemental analysis. Moreover, a mechanism for the reaction was proposed.

Key words: 1-isothiocyanatobenzene, 2-aminothiophenes, cyclization reaction

CLC Number: 

  • O626.12
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